General Information

Mail: University of Houston
Cullen College of Engineering
E421 Engineering Bldg 2, 4722 Calhoun Rd, Houston, TX 77204-4007
Map & Driving Directions (includes parking information)
Email: info [at] egr [dot] uh [dot] edu


University of Houston Cullen College of Engineering


Party, Exercise, Repeat: Can Exercise Protect the Brain From the Effects of Binge Drinking?

Printer-friendly versionSend by emailPDF version


Toby Weber
Dr. Badri Roysam and Dr. Leigh Leasure look over brain images with a graduate student researcher.

If you’ve ever lived through a hangover, you are probably already familiar with the unpleasant, lingering side effects that a night of binge drinking can have on the brain: when you wake up the next day, the sunlight seeping through your window burns your retinas, your brain feels like it’s coated with goo and it’s impossible to focus, let alone think.

But what if hitting the gym prior to hitting the bars could make your hangover the next morning a little less painful? Or, at the very least, what if exercise has a neuro-protective effect, reducing the negative (and oftentimes long-term) effects that binge drinking has on the brain? That’s what ECE chair Badri Roysam is trying to find out in a research collaboration with a UH psychology faculty member.

The collaboration with associate professor Leigh Leasure involves the analysis of 3-D images of brain tissues from animal models using Roysam’s FARSIGHT software suite. This is a quantitative histopathology tool that can be used to analyze tissue images to identify and quantify cell and tissue alterations caused by binge alcohol consumption, pre- and post-binge exercise, and potential protective drug treatments.

While Leasure has spent much of her career studying the brain in different states and its response to different stimuli, FARSIGHT will enable investigations that are much broader as well as much deeper. While many of her earlier research efforts had to target specific cell or tissue types, “the power of FARSIGHT is to get very precise measurements on many different tissue parameters. We can look at everything from the size of neurons, the number of glia, and the proximity of glial cells to vasculature,” she said.

In addition, “we can do hypothesis testing. We can look and see if what we think is going to happen is actually happening. And we can do exploration. What else is going on that we don’t know about? We’ve never had the potential to look at things in a global fashion before.”

While their initial work will focus on alcohol and exercise, Leasure and Roysam plan to expand their collaboration to include the study of multiple brain states, including neurodegenerative diseases and aging.

One particular area of interest in all these studies will be the brain’s blood vessels and its glial cells, which help maintain chemical balance in the brain and aid in communication among neurons. The glial-vascular complex, said Leasure, is key to supporting the health of neurons. And since glia and vasculature regenerate (while neurons typically don’t) they should in many ways be easier to influence, making them good targets for future therapies and medications.




Related News Stories

PHOTOS: John Rogers Shares the Future of Soft Electronics for the Human Body at Engineering Rockwell Lecture

Imagine an electronic “tattoo” on your skin that could continuously monitor your health, or tiny, biocompatible sensors that could treat a traumatic brain injury at the site. It may seem like science fiction, or at least a dream of a very distant future – but as John Rogers of Northwestern University explained to the UH community last week, these are both current examples of biocompatible devices that can integrate with the human body.

MRI-Powered Mini-Robots Could Offer Targeted Treatment

Invasive surgical techniques – cutting through the breastbone for open heart surgery or making a large incision to inspect an abdominal tumor – allow physicians to effectively treat disease but can lead to sometimes serious complications and dramatically slow healing for the patient.

Upcoming Events / Seminars